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Sickle cell anaemia is single point mutation in position 6 of globin chain by valine replacing glutamic acid resulting to sickling and polymerization of red blood cells. This affects the supply of oxygen and vaso-occulisve crisis may set causing many systemic damages and creates great burden to the parents and the entire society.The burden of sickle cell anaemia is still high in Africa not minding the level of awareness in the society. The selective protective advantage of protection of sickle cell trait due the endemicity of malaria may be a major factor on the burden level in Africa as well as some culture. More sickle cell education should be given in public places and included in the curriculum of different levels of education for prevention.

Osteomyelitis can happen if a bacterial or fungal infection enters the bone tissue from the bloodstream, due to injury or surgery. Most often the bacteria are staphylococcus, but in sickle-cell children, both salmonella and staphylococcus are implicated. The bacteria are haematogenously disseminated and deposited in the trabecular bone or marrow, usually in the metaphysis of the proximal tibia or distal femur. Oteomyelitis manifests in patients with sickle cell anaemia when there is infections thorough some bacteria and could affect the bones with attendants effect in the activity of bone marrow which will affect the solid phase of blood and the quality of lives of the sickle cell anaemia patients. Preventive measures such personal hygiene should be adopted to avoid the danger such inflammation could cause in the patients.